This section details the primary medications, which are typically taken by all household members simultaneously:
Pyrantel Pamoate: This medication is widely used and is available over-the-counter (OTC). It works by acting as a neuromuscular blocking agent, paralyzing the adult worms so they are expelled naturally in the stool. For standard adult and pediatric patients, the dosage is 11 mg/kg (up to a maximum single dose of 1 g). The dose is repeated in two weeks. It is generally well-tolerated, with only mild gastrointestinal side effects occasionally reported. Mebendazole: This is a prescription-only, highly effective medication. Its mechanism involves inhibiting microtubule formation within the parasite, which irreversibly blocks glucose uptake and depletes the worm's energy. It is administered as a single 100 mg oral dose for adults and children, repeated in two weeks. Systemic absorption is low, which helps minimize side effects. Albendazole: Also available only by prescription, albendazole is often preferred when multiple types of parasitic infections might be present. It functions similarly to mebendazole, degrading the cytoplasmic microtubules in the parasite’s intestinal cells. The standard dosage is a single 400 mg oral dose (reduced to 200 mg for children aged 12–24 months), with the dose repeated in two weeks.